KOPVILLEM INSTITUTE OF MEDICAL PHYSICS RUSSIAN ACADEMY OF TECHNOLOGICAL SCIENCES
About Institute Equipment Sertification Laser Equipment Treatment Science Projects


Science projects:

1. Interferon Induction (II)

      There is the hiperinduction of interferon under the influence of Low Level Laser Therapy Light. ("MC-5").

Interferon Induction graph

2. The Influence of Low Level Laser Light on Biological Object (ILBO)

The Influence of Low Level Laser Light on Biological Object graph

3. New phenomenon: photoinduced enzyme reaction

      The researches of an opportunity of low level laser light (LLLL) influence on enzyme reaction parameters have been maid. This follows from the physical models considering enzymatic reaction as a nonadiabatic multiquantum process with the conformation degrees of freedom (CDF) contribution. According to the theory the high-frequency fluctuations in the active enzyme center (AEC) influence on CDF. And these high-frequency fluctuations in AEC can be easily excited by external electromagnetic field of the certain frequency. In experiment with system - a water solution of concanavalin A (ConA), glucose and salts of Er under action of helium - neon LLLL glucose epimeres - allose, mannose and galactose were received. KonA is the lectin - protein that can bind carbohydrates in biopolymers. Presumably, basic physiological functions of KonA are carbohydrate transport and accumulation. The observed glucose photoepimerisation is photoinduced enzyme reaction in which under the action of LLLL and with presence of a photosensitizer the albumen effectively reforms the glucose to epimeres. The important role of this experiment is that ConA has shown enzymatic activity that was never observed earlier.

4. Natural laser therapy

      Various energetic parameters of low level laser therapy (LLLT) systems were studied to find the most close to the nature. LLLT system energy characteristics such as average power and energy in spectral region do not surpass a natural background maximum level (BML). However for spectral light density (SLD) and pulse power the energy characteristics of LLLT system are very different. The pulse power of pulse lasers exceeds natural BML in hundreds times. On SLD parameter the semi-conductor and diode lasers with continuous or amplitude-manipulated signal are most close to the natural level of a sunlight on the Earth (0,1 mW/cm2nm). Due to high monochromaticity the light of the helium - neon laser on a maximum of spectral density surpasses similar parameters for the semi-conductor laser of the same power and natural BML in tens and hundred thousand times. Thus only light of semi-conductor LLLT system with continuous or amplitude-manipulated signal does not exceed natural BML. Therefore the laser therapy with these devices is the natural laser therapy. The LLLT system MC-5 operates in amplitude-manipulated mode on the wavelength of 780 nm and effectively treats various diseases. Among other semi-conductor systems MC-5 is the champion on impact of the endogenous interferon hyperinduction mechanism.

5. Endogenous protoporphyrin IX is photosensitizer for photodynamical therapy

      The purpose of researches - the search of the minimally toxic photosensitizer and the source of red or near infrared light capable to activate this chromophore. Luminescence spectra of plasma of fresh human venous blood with added erythrocytes of the same blood were studied. Excitation of a luminescence was carried out on length of a wave 337,1 nm. The part of the added erythrocytes was mechanically destroyed. Fluorescence spectra of pure endogenous protoporphyrin IX and protoporphyrin IX conjoined with protein were found out. In the latter case the maximum of radiation of 0-0 strips lays on length 642 nm. From here follows, that protoporphyrin IX connected with protein will actively absorb radiation on wavelength 632 - 634 nm. It is important because the wavelength of He-Ne laser lies in this region. Thus, the conjunction of endogenous protoporphyrin IX and the protein is the photosensitizer for PDT. It is obvious that such photosensitizer will be the minimally toxic.

6. Percutaneous polychannel laser disk decompression

      The purpose of research is the improvement of percutaneous laser diskectomy and decompression methods, which in comparison with percutaneous endoscopic diskectomy and in particular open spinal diskectomy are considerably less traumatic method of treatment of disk hernias. The method of percutaneous polychannel laser disk decompression (PPLDD) was developed and patented which consists of formation from one puncture consistently several cavities. The total volume of cavities is about only 0.2 cm3. The result of laser radiation of the semiconductor laser "LAZON 10P" (ALOD-01 and LS-0.97) with a wavelength of 965 nm is vaporization and photocoagulation. More than 600 patients was successful treated. The recourse of neurologic semiology was marked in the nearest hours after operation. For the majority of patients pain in a leg disappeared, the sensitivity, the static and the biomechanic of a backbone was improved or restored. In most cases the control research showed the reduction of disk hernia up to 50 % and, sometimes, up to full hernia dissipation. The 83 % of patients have returned to the usual activity in one month after treatment. Thus, PPLDD allows to reduce the traumatization and the period of recovery.

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